Ralph Muller is considered to be a titan in the healthcare industry with three decades of experience leading two of America’s top 10 hospitals. Profound knowledge in improving management and delivery of healthcare. 

Ralph was from 2003-19 the CEO of the University of Pennsylvania Health System (UPHS), where he helped transform Philadelphia’s healthcare landscape, improve patient access and support breakthrough innovation. Under Ralph’s leadership, UPHS grew into a world-renowned, academic medical center-based health system caring for more than 5 million patients annually. A signature effort of his tenure is the creation of the Penn Medicine Center for Healthcare Innovation, which brings together physicians, nurses and social scientists to test new healthcare models.

Prior to UPHS, Ralph was  from 1985-2001 the President of the University of Chicago Hospitals and Health Systems. While at the University of Chicago, Ralph also served as the budget director and later as the deputy dean of the Division of Biological Sciences at the Pritzker School of Medicine. Ralph previously held senior roles with the Commonwealth of Massachusetts, including as deputy commissioner of the Massachusetts Department of Public Welfare, where he was responsible for the state’s major welfare programs, including Medicaid. Ralph also was a visiting fellow at the Kings Fund in London, U.K.

In addition, Ralph has held many senior leadership positions at prestigious national healthcare organizations and associations. Well known for his strong community engagement, he led the creation of the Penn Medicine High School Pipeline program to strengthen educational opportunity for West Philadelphia students, and the Penn Medicine CAREs grant program, which supports more than 180 community service initiatives. 

At Penn Medicine

Penn Medicine is one of the world's largest and most impactful medical centres. Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $8.9 billion enterprise.

  • The celebrated architect of Penn’s business transformation is Ralph Muller, (CEO, 2003-19).

  • An industry pioneer and leader, who has also nurtured 21 CEOs serving within the US healthcare system.

  • Today, Penn Medicine has become a $8.9 billion enterprise with more than 40,000 employees – ranked among the top US research institutions and is considered at the forefront of medical innovation.

  • Developed mRNA technology (behind the Pfizer and Moderna COVID-19 vaccines).

  • Developed immunotherapy - Pioneer in using CAR T cell therapy to cure B-cell acute lymphoblastic leukemia. 

  • Developed personalized cancer vaccines.

  • Developing technologies for the world’s first gene therapies, curing blindness and other genetic disorders.

  • Over the last three years Penn has received 13 US FDA approvals tied to research breakthroughs, treatments, and techniques developed in their labs.